The two self-designed of centrifugal pump with small vane and centrifugal pump without small vane were simulated numerically to select a centrifugal pump with higher efficiency. The internal flow characteristics of the centrifugal pump was simulated by using Reynolds time-averaged N-S equation and RNG turbulence model to obtain pressure and velocity distribution and the cavitation characteristics were simulated by using SST turbulence model and Schnerr-Sauer cavitation model to obtain the gas volume fraction distribution. The results show that at the same flow rate, the change of velocity in the pump cavity of centrifugal pump with vane is smoother and the gas volume is less, but the back-flow is aggravated near the small vane, especially when interacting with the tongue, and a large amount of gas is generated at the suction surface of the small vane. In addition, the efficiency of centrifugal pump without vane is higher than that of centrifugal pump with vane, which provides a basis for the structural optimization of centrifugal pump.